| 2006 Missouri
Southern Football Schedule
Schedule is subject to change 5-6, 3-6 MIAA |
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| DATE | OPPONENT | LOCATION | LIVE STATS | TIME/RES. |
| Sat., Sept. 2 | Ouachita Baptist | Joplin | LIVE STATS | W, 28-22 |
| Sat., Sept. 9 | @ Harding | Searcy, Ark. | W, 30-27 | |
| Sat., Sept. 16 | Southwest Baptist * | Joplin | LIVE STATS | W, 42-21 |
| Sat., Sept. 23 | @ #13 Pittsburg State * (U.S. Cellular Miner's Bowl IX) | Pittsburg, Kan. | L, 48-24 | |
| Sat., Sept. 30 | #2 Northwest Missouri State * | Joplin | LIVE STATS | L, 24-7 |
| Sat., Oct. 7 | @ Truman * | Kirksville, Mo. | L, 35-28 | |
| Sat., Oct. 14 | #16 Missouri Western * (Homecoming) | Joplin | LIVE STATS | L, 24-17 |
| Sat., Oct. 21 | Central Missouri State * | Joplin | LIVE STATS | W, 31-26 |
| Sat., Oct. 28 | @ Fort Hays State * | Hays, Kan. | L, 10-0 | |
| Sat., Nov. 4 | Washburn * | Joplin | LIVE STATS | L, 14-13 |
| Sat., Nov. 11 | @ Emporia State * | Emporia, Kan. | W, 34-33 | |
| * Mid-America Intercollegiate Athletics Association Game | ||||
| All times Central | ||||
| Home games in bold | ||||